HIV–1 Integrase: Mechanism and Inhibitor Design

Provides the Foundation Needed to Design Effective HIV–1 Integrase Inhibitors Around the world, scientists have been working for years with the goal of designing effective HIV–1 integrase inhibitors in the battle against AIDS. This book reviews all their latest research findings on both inhibitor design and the mechanisms of action of HIV–1 integrase. Chapters have been contributed by leading pioneers in the field from North America, Europe, and Asia. These contributions represent not only a thorough review of the current literature, but also the authors? firsthand experience in drug development and design. Coverage includes such topics as: Integrase mechanism, structure, and function HIV–1 integrase–DNA interaction Host factors affecting provirus stability and silencing Role of metals in HIV–1 integrase inhibitor design Historic perspectives, challenges, and future opportunities As the first publication to comprehensively examine HIV–1 integrase, this book is essential reading for anyone involved in inhibitor drug discovery. Integrates chemical, biochemical, and biological approaches, enabling readers to take full advantage of a promising target enzyme for combating HIV and retroviruses Illustrates rational drug design for a complex drug target with plenty of step–by–step examples Addresses drug design issues from a variety of perspectives to help readers understand both the challenges and opportunities of developing a successful HIV–1 integrase inhibitor This book fills an important gap in the review literature, offering a valuable introduction to the field for scientists who need to collaborate with researchers in several disciplines in order to design drugs that effectively target HIV–1 integrase.