Palladium–Catalyzed Coupling Reactions: Practical Aspects and Future Developments

This handbook and ready reference brings together all signifi cant issues of practical importance in selected topics discussing recent significant achievements for interested readers in one single volume. While covering homogeneous and heterogeneous catalysis, the text is unique in focusing on such important aspects as using different reaction media, microwave techniques or catalyst recycling. It also provides a comprehensive treatment of key issues of modern–day coupling reactions having emerged and matured in recent years and emphasizes those topics that show potential for future development, such as continuous flow systems, water as a reaction medium, and catalyst immobilization, among others. With its inclusion of large–scale applications in the pharmaceutical industry, this will equally be of great interest to industrial chemists. From the contents ? Palladium–Catalyzed Cross–Coupling Reactions – A General Introduction ? High–turnover Heterogeneous Palladium Catalysts in Coupling Reactions: the Case of Pd Loaded on Dealuminated Y Zeolites Palladium–Catalyzed Coupling Reactions with Magnetically Separable Nanocatalysts ? The Use of Ordered Porous Solids as Support Materials in Palladium–Catalyzed Cross–Coupling Reactions ? Coupling Reactions Induced by Polymer–Supported Catalysts ? Coupling Reactions in Ionic Liquids ? Cross–Coupling Reactions in Aqueous Media ? Microwave–Assisted Synthesis in C–C and C–Heteroatom Coupling Reactions ? Catalyst Recycling in Palladium–Catalyzed Carbon–Carbon Coupling Reactions ? Nature of the True Catalytic Species in Carbon–Carbon Coupling Reactions with ? Heterogeneous Palladium Precatalysts ? Coupling Reactions in Continuous Flow Systems ? Large–Scale Applications of Palladium–Catalyzed Couplings in the Pharmaceutical Industry