Mass Spectrometry in Drug Metabolism and Disposition: Basic Principles and Applications

The pioneering guide to solving real–world problems in drug metabolism using mass spectrometry Mass spectrometry has become the predominant analytical tool for drug metabolism and pharmacokinetics research in modern drug discovery and development. This book represents a coherent integration of all relevant background knowledge and detail surrounding the analytical technologies in this new multidisciplinary field. With chapters written by internationally renowned authors, the book provides details on: Basic concepts of drug metabolism and pharmacokinetics The principles and common practice of mass spectrometry in drug metabolism Applications of new LC/MS techniques in drug metabolism and disposition Mass Spectrometry in Drug Metabolism and Disposition examines fundamental aspects and practical considerations of using mass spectrometry in drug metabolism such as biotransformation reactions, metabolizing enzymes, transporters and drug–drug interactions, drug metabolism in drug design and development, theory and instrumentation of mass spectrometry, and LC/MS approaches to drug metabolism and mass spectral interpretation. Exciting details on new mass spectrometry technology and novel applications used in the frontiers of pharmaceutical research, including high–resolution mass spectrometry in metabolite identification, imaging mass spectrometry in drugtissue distribution, accelerator mass spectrometry in microdosing, as well as theanalyses of metabolomes, herbal medicine, biomarkers, and biologics by various mass spectrometers are also highlighted in the book. This unique book serves as both a textbook for students as well as a comprehensive reference for pharmaceutical professionals, offering fresh and exciting solutions in the ongoing effort to design and develop drugs that are both effective and safe.